Past events

Basic Course in Molecular Pathology

for residents in pathology

This course is organized by The Belgian society of Pathology and the Working group of Molecular Pathology.
It is mandatory for residents during their training.
An exam will be organized in due course.

 

Program

DAY 1 - Friday

10:00

Course introduction

 

10:10

 

 

 

 

 

 

 

10:40

An introduction to cancer cell genetics/epigenetics
Types of DNA mutations: a vocabulary

  • Translocations/rearrangements
  • Insertions/deletions
  • Inversions
  • Amplifications
  • Point mutations (missense, nonsense, silent, inframe, frameshift)

Epigenetics

  • Mechanisms
  • Bv. MGMT

11:10

Break

 

11:20

 

12:00

DNA repair and genome integrity

DNA mismatch repair – microsatellite instability (IHC vs. PCR vs. NGS)

DNA breaks (SSB-DSB; synthetic lethality in HRD)

12:40

Lunch

 

13:30

14:10

Signaling pathways in cancer

Oncogenes (EGFR-RAS-RAF-PIK3CA)

Tumor suppressor genes (p53-PTEN-Rb-CDKN2A-NF)

 

14:40

15:30

An introduction to onco-immunology

Basics

Biomarkers

16:00

End of day 1

 

DAY 2 – Saturday

10:00

Fluorescence in situ hybridization: practical aspects

10:30

Liquid biopsy: introduction and clinical applications

11:00

Break

 

11:10

Next generation sequencing

General introduction: the basics of NGS

12:00

Lunch

12:30

NGS data analysis: practical aspects (pre-analytics, variant interpretation theory, tarification rules)

13:50

Break

14:00

Practical cases: how to solve your problems?

15:00

Closure

15:15

End